Scientists at the University of British Columbia have successfully performed the first human transplantation using a kidney enzymatically converted from blood type A to the universal type O. The conversion process involves removing blood type-defining sugars from the organ, potentially reducing wait times and rejection risk for patients needing transplants. Initial observations post-transplant indicate the kidney functioned without hyperacute rejection for two days, with mild immune responses emerging thereafter but less severe than typical mismatched transplants. This breakthrough, published in Nature Biomedical Engineering, offers a promising step toward broader use of blood-type incompatible organs.