Researchers reported in Nature Communications that combining bacteriophage therapy with traditional antibiotics cleared refractory Klebsiella pneumoniae peritonitis in a preclinical model of peritoneal dialysis‑related infections. The team led by Yang, Wu, and Jiang showed synergy between phage and antibiotic modalities where each alone failed. The study detailed experimental design, dosing regimens and pathogen clearance metrics, positioning phage‑antibiotic combos as a candidate strategy for multidrug‑resistant Gram‑negative infections. The work provides mechanistic data supporting translational development of adjunctive phage therapies. Authors emphasized that controlled clinical trials will be required to define safety, dosing and resistance dynamics before wider clinical use.
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