ASH and ISTH released new clinical guidance for anticoagulant prophylaxis in pediatric patients at risk of venous thromboembolism (VTE) outside cardiac indications. Published in Blood Advances, the guidelines cover non-cardiac pediatric populations and aim to standardize decision-making for thrombosis risk prevention. The release is intended to address a practice gap where pediatric VTE prophylaxis strategies vary by institution. For clinicians and trial designers, the document provides a structured framework to improve consistency in how risk is stratified and prophylaxis is used.