Biomedical engineers at UNC-Chapel Hill and North Carolina State University reported development of an injectable microgel intended to reduce bleeding in infants undergoing surgery. In Science Advances, Ashley Brown and colleagues describe hemostatic B-knob-triggered microgels (BK-TriGs) that reduced bleeding by at least 50% in an animal model. The work is framed around neonatal-specific coagulation differences that can make transfusing adult blood products risky, including higher thrombosis risk and potential morbidity in neonates. The authors said BK-TriGs are designed for neonatal clotting mechanisms to address bleeding while potentially reducing reliance on adult transfusions. If the translational package holds up, the platform could offer a targeted hemostasis approach for pediatric surgical settings with unmet needs in safer blood-loss management.