Pediatric and neonatal medicine have seen critical advances ranging from novel imaging technologies to therapeutic regimens. Notable developments include Boston Children’s Hospital, Dana-Farber, and Broad Clinical Labs launching a pediatric cancer genomics initiative (BrightSeq) offering combined tissue and liquid biopsy sequencing; research uncovering the importance of punctate white matter lesions for cerebral palsy risk prediction; studies identifying approaches to reduce sedation risks during pediatric MRI; and the launch of exercise intervention trials to improve outcomes in pediatric oncology. Collectively, these innovations promise improved diagnosis, treatment personalization, and long-term prognostic capabilities for pediatric populations.