Parse Biosciences and Codebreaker Labs entered a collaboration to combine engineered variant libraries with Parse’s single‑cell transcriptomics platform to map how genetic variants affect cell states at scale. The partnership aims to generate functional datasets that connect rare variants to disease‑relevant transcriptomic signatures, with applications in target discovery, AI model training and precision trial design. The alliance follows Parse’s recent partnerships to build very large single‑cell perturbation datasets and comes amid Qiagen’s acquisition of Parse. The companies said the combined platform will enable experimental validation of variant effects on single cells—an approach that could refine whole‑genome interpretation and speed translational decision‑making. Such high‑throughput functional genomics work is positioned to feed machine‑learning models and accelerate target triage in preclinical pipelines.