Multiple studies reveal new understanding of Parkinson’s disease (PD) mechanisms and interventions. These include digital speech biomarkers measuring levodopa effects, enzyme inhibition restoring neuroprotective pathways in mutant LRRK2 mouse models, EEG markers identifying cognitive impairment in REM sleep behavior disorder, and investigations into brain iron accumulation. Additionally, novel TMS protocols and cell signaling studies offer avenues for refined symptom management and precision therapies.