Recent studies underscore novel biomarkers and pathological features in Parkinson’s disease and atypical parkinsonism. One cohort study, published in npj Parkinson’s Disease, identified significant changes in cutaneous nerve fibers, providing accessible diagnostic potential. Another study linked altered perivascular space fluid diffusivity with early Parkinson’s decline, utilizing advanced diffusion-weighted MRI for prognosis. These findings reveal peripheral and cerebrovascular contributions to disease pathology, offering avenues for early detection and therapeutic targeting.