New therapeutic strategies for Parkinson’s disease emerge from studies examining neural modulation and gut microbiome interventions. Deep brain stimulation at theta frequencies improved cognitive conflict resolution, presenting a novel neuromodulation approach. Concurrently, a pilot study demonstrated the safety and tolerability of fecal microbiota transplantation, highlighting the gut-brain axis's role in neurodegeneration. Together, these findings open innovative avenues for managing motor and non-motor symptoms of Parkinson’s.