Researchers published PanMAN (Pangenome Mutation‑Annotated Network), a data structure and compression approach in Nature Genetics designed to dramatically reduce storage and compute burdens for pangenomics. PanMAN encodes phylogenies, mutations and whole‑genome alignments into a mutation‑annotated tree with a multi‑level coordinate system, enabling population‑level reference representation and evolutionary compression. The method aims to lower both storage costs and the computational footprint of large comparative genomics projects, a bottleneck as sequencing scales to millions of genomes.