Pacific Biosciences announced sequencing chemistry and consumable workflows that let customers wash and reuse SMRT cells on Revio instruments, plus a new Sprq‑Nx chemistry that boosts output and adds 5‑hmC detection. PacBio projects cost reductions up to 40% for large projects, bringing per‑genome consumable costs close to $300 for 20× coverage and challenging short‑read cost economics. South Korea selected PacBio HiFi sequencing for its national pangenome project to generate telomere‑to‑telomere assemblies for over 1,000 genomes, underscoring demand for long‑read platforms for population reference building. PacBio CEO Christian Henry framed the move as pivotal for the company’s competitiveness on price per genome. Technical note: Long‑read, high‑fidelity sequencing improves structural variant detection and complex region assembly; lowered consumable costs materially shift genomics project economics for biobanks and national pangenomes.