Pacific Biosciences partnered with DNAstack to host a federated environment for sharing HiFi long‑read whole‑genome sequencing data across the HiFi Solves Global Consortium. The platform enables institutions in 15 countries to query and analyze data without centralizing patient data, maintaining regional privacy controls while accelerating rare‑disease discovery. The federated model supports secure variant filtering and cross‑site interpretation using PacBio’s HiFi reads, aimed at shortening diagnostic timelines and improving the accuracy of structural and complex variant detection. Consortium leaders said the approach fosters diverse, multi‑national datasets that strengthen variant interpretation for underserved populations and speed clinical answers for families with rare genetic diseases.