Researchers reported a scalable method to produce thousands of human kidney organoids and demonstrated their integration into porcine kidneys using ex vivo normothermic perfusion. Teams infused human organoids into perfused pig kidneys and monitored engraftment—representing a major step toward organoid‑augmented xenotransplantation and translational applications such as drug screening and regenerative therapies. The two companion reports describe both the manufacturing process enabling uniform, high‑throughput organoid generation and the first demonstrations of organoid survival and functional integration in porcine hosts. The approach may accelerate preclinical models and bolster efforts to address donor organ shortages, while raising questions about immunogenicity, scale for human use, and regulatory pathways for hybrid grafts.