A comprehensive cohort study led by NYU Langone Health and Perlmutter Cancer Center has identified specific oral bacterial and fungal species, including Candida yeast and periodontal pathogens, associated with a 3.5-fold increased risk of pancreatic cancer. Utilizing shotgun metagenomic and ITS sequencing of saliva samples from 122,000 individuals over nearly 9 years median follow-up, researchers fashioned a microbial risk score composed of 27 microbial species predictive of pancreatic cancer risk. These findings point to the oral microbiome as a promising biomarker for personalized pancreatic cancer prevention.