A new computational pipeline, HiFIseek, aims to identify hidden cancer-driving mutations in the genome’s non-coding regulatory regions. The tool systematically links damaging variants to cancer genes and reported that regulatory regions for established drivers—including BRCA1—are enriched for high-impact variants. The work highlights a growing effort to move beyond coding mutations when explaining tumorigenesis and to improve discovery for targets that may be missed by standard variant-calling workflows. If validated across independent cohorts, such pipelines could change how genomic panels prioritize non-coding variants for both research follow-up and precision oncology interpretation.