A team reported a human multi-organ chip that models cancer metastasis by simulating organ colonization and niche remodeling. The platform includes compartmentalized engineered bone and lung tissues with vascular flow carrying circulating breast cancer cells, enabling controlled assessment of adhesion, traversal through endothelium, and adaptation after colonization. The approach is positioned as a patient-specific, human model to study mechanisms often difficult to evaluate in animals, especially the organ colonization stage. The group published the work in Science Translational Medicine, describing how the chip supports molecular pathway discovery and therapeutic target identification for metastasis. The study also demonstrates feasibility by probing colonization patterns of circulating human breast cancer cells in bone and lung tissues, illustrating how engineered microenvironments can reproduce key metastatic constraints outside living organisms.