Researchers identified a mobile-cell platform approach to track and map long-lived plasma cell behavior inside a human bone marrow-on-a-chip (BMOC) system, reported in Science Advances. The work recreated the bone marrow niche using endosteal and perivascular channel components and used the model to study how plasma cells migrate, localize, and continue moving while retained. Beyond imaging plasma cell dynamics, the team reported niche signals implicated in proper localization and persistence of antibody-secreting cells. The platform is intended to make it easier to interrogate how the marrow environment maintains long-term immunity and how disruption may contribute to disease. For translational research, the chip-based niche model could reduce reliance on animal or two-dimensional systems for questions where spatial and cell-cell interactions drive outcomes.