New research reveals NSUN7-mediated m5C modification of circNTRK2 sustains glioblastoma stem cell properties, supporting tumor maintenance and therapy resistance. The study shows NSUN7 alters RNA methylation patterns that stabilize oncogenic circular RNAs, promoting self-renewal. Authors propose RNA-modification enzymes as druggable nodes to disrupt glioma stemness and sensitize tumors to standard therapies; translational work is needed to develop specific inhibitors.