Scientists reported a rapid method to generate functional vascular organoids from human induced pluripotent stem cells by simultaneous activation of endothelial and mural transcription factors, ETV2 and NKX3.1. This approach allows cells to self-assemble into microvascular networks within days, showing perfusion and integration after transplantation in animal models. The method offers independent control of vascular cell types, advancing vascular biology, tissue engineering, and regenerative medicine platforms.