Scientists using genome-wide CRISPR screens have uncovered the GATOR1 complex as a critical tumor suppressor in Myc-driven lymphoma. This regulatory axis impedes cancer progression by modulating amino acid sensing pathways, specifically mTORC1 activation. Complementary studies reveal that the GATOR1 complex suppresses aggressive blood cancers, offering a new molecular target for therapeutic interventions. These findings, published in Nature Communications and JAMA Oncology, provide a foundation for potential precision treatments aiming to restore or mimic GATOR1 function in hematologic malignancies.