Cutting-edge discoveries continue to deepen understanding of cancer biology and therapeutic opportunities. Highlights include: Genomic identification of follicular lymphoma subtypes with distinct molecular and clinical features; multi-omics analysis revealing T-cell exhaustion mechanisms in chronic lymphocytic leukemia; epigenetic targeting of NSD2 for oncogenic chromatin remodeling; bispecific antibodies targeting T-cell engagement in solid tumors and lymphomas; and natural compound potential, such as dendrosomal nanocurcumin inhibiting breast cancer signaling pathways. These studies advance precision oncology and immunotherapy development.