University of Pennsylvania researchers discovered that a single dose of psilocybin rapidly and sustainably alleviates both chronic pain and associated depressive-like behaviors in mouse models. The study identified specific brain circuits modulated by psilocybin, pinpointing serotonin receptors responsible for the analgesic and mood-enhancing effects. These findings open avenues for non-addictive, non-opioid therapies targeting comorbid pain and mood disorders.