An international research consortium developed a polygenic risk score (PGS) based on genetic data from over five million people capable of predicting a child's likelihood of developing adult obesity before age five. Published in Nature Medicine, the study highlights the PGS's predictive power across life stages and ancestries, offering opportunities to identify high-risk children for early lifestyle or medical interventions. The approach integrates genomics with public health strategy amid rising global obesity rates expected to affect over half the population by 2035.