Scientists at King’s College London have developed a nanoneedle patch containing tens of millions of microscopic silicon needles, thousands of times thinner than a human hair, that collects molecular diagnostic data directly from living tissues without causing pain or tissue damage. This innovative device, reported in Nature Nanotechnology, facilitates real-time lipidomics and molecular analysis, enabling repeated sampling from the same area and potential for earlier diagnosis and monitoring of diseases including cancer and neurodegenerative conditions. The technology promises to transform clinical monitoring by providing minimally invasive, spatiotemporally precise molecular insights inaccessible by traditional biopsies.