Research into cancer therapeutics is progressing with discoveries of molecular mechanisms and innovative treatment strategies. Key findings include a novel BTK inhibitor inducing tumor cell apoptosis and the role of CITED4 in gemcitabine resistance in pancreatic cancer. Studies reveal the antitumor effects of fenofibrate in bladder cancer via immune modulation and explore propranolol's potential as an adjunct cancer treatment. Molecular targets such as SPANXB1 are implicated in brain metastasis from breast cancer, and advancements in nanotherapeutics harness ultrasound-driven catalytic PANoptosis for tumor suppression.