Cutting-edge research reveals critical molecular mechanisms in various cancers, presenting new therapeutic targets. Studies identify COL6A6 as an immune-associated tumor suppressor in breast cancer microenvironments, ERBB3’s role in ferroptosis regulation in gastric cancer, and ATOX1’s promotion of hepatocellular carcinoma progression via c-Myb/PI3K/AKT axis. Additionally, circ_0000847 circular RNA drives colorectal cancer progression and WTAP protein is implicated in liver cancer DNA repair. These advances offer promising avenues for targeted oncology drug development.