Researchers at the Arc Institute have developed a universal bridge recombinase platform that expands gene editing capabilities beyond small mutations to enable large-scale genomic rearrangements in human cells. This RNA-guided system facilitates programmable insertion, deletion, and inversion of DNA segments at the megabase scale with up to 20% efficiency. The breakthrough, detailed in Science and Nature, unlocks possibilities for broad therapeutic genome engineering and modeling of complex diseases. Such technology could revolutionize gene therapies by allowing the restructuring of large genetic regions, aligning editing scale with natural evolutionary mechanisms.