Innovations in bioengineering are advancing drug delivery modalities. Researchers at Technical University of Munich developed multifunctional hollow microspheres comprising mucus and polydopamine optimized for adjustable therapeutic cargo delivery within biological environments. Separately, dissolving microneedles demonstrated efficacious delivery of treatment agents in rectal cancer models, potentially improving localized administration. These technologies represent promising progress in precision and minimally invasive drug delivery in oncology and other fields.