A recent Nature Biotechnology publication details a strategy to eradicate methicillin-resistant Staphylococcus aureus (MRSA) infections by inducing calcification on bacterial surfaces, thereby boosting immunogenicity and bacterial clearance. The method involves antibody–polysialic acid conjugates that promote calcium deposition, effectively encasing bacteria and enhancing immune system recognition in mouse models. This innovative approach could address the pressing challenge of antibiotic resistance and offers a potential therapeutic avenue distinct from traditional antimicrobials.