Northwestern University researchers published a proof‑of‑concept for HYDRACs—heterobifunctional proteomimetic polymers that bind undruggable oncoproteins like MYC and KRAS and recruit cellular degradation machinery. The protein‑like polymers display multiple targeting peptides and degron motifs, enabling selective engagement and proteasomal clearance of disordered oncogenic drivers in cell lines and tumor‑bearing mice. The approach sidesteps the need for classical ligandable pockets and demonstrated tumor accumulation, on‑target gene expression changes, and slowed tumor growth in preclinical models.