Researchers at Northwestern reported HYDRACs—heterobifunctional proteomimetic polymers that recruit cellular degradation machinery to remove previously “undruggable” oncoproteins such as MYC and KRAS. The polymers display multivalent recognition motifs that engage disordered targets and degrons that recruit the cell’s quality‑control systems, inducing selective degradation in cancer cell lines and tumor models. In cell culture, HYDRACs reduced target protein levels and triggered cancer cell death; in mouse tumor models, polymer accumulation correlated with decreased proliferation and tumor growth arrest. The work, reported in Nature Communications, presents a chemistry‑forward route to eliminate proteins lacking classical ligandable pockets. The approach broadens modalities for tackling challenging oncology targets and presents new CMC and delivery considerations for polymeric degrader therapeutics.