A Clinical Toxicology study from King’s College London found that fatalities involving nitazene synthetic opioids may be undercounted by as much as one‑third, owing to limitations in toxicology testing and chemical variability among nitazene analogs. The research indicates official death statistics may understate the scale of nitazene‑linked mortality in the UK. Nitazenes are a class of highly potent synthetic opioids that have emerged in illicit drug markets. The study’s findings call for expanded analytical screening, standardized postmortem protocols and enhanced surveillance to inform public‑health responses and harm‑reduction programs.