The U.S. National Institutes of Health has granted $87 million over three years to establish the Standardized Organoid Modeling Center (SOMC), supporting the transition from traditional animal testing to advanced organoid models in biopharmaceutical research. This initiative aligns with the FDA’s roadmap promoting alternative approaches for drug development, aiming to improve reproducibility and predictability in preclinical studies by standardizing organoid protocols. The center will enhance disease modeling and therapeutic screening, potentially expediting safer and more ethical drug development.