A new two-year research initiative funded by the NIH’s National Institute of Environmental Health Sciences is investigating molecular mechanisms by which per- and polyfluoroalkyl substances (PFAS) affect male reproductive health prior to conception. Led by researchers at Wayne State University, including doctoral candidate DruAnne Maxwell and professor Richard Pilsner, the multidisciplinary study will explore epigenetic and toxicological pathways mediating PFAS interactions with spermatogenesis and potential impacts on offspring health. This work addresses a gap in reproductive toxicology focusing on paternal environmental exposures, with implications for understanding PFAS as environmental contaminants.