More than 300 current and former NIH staff have signed the Bethesda Declaration protesting severe funding cuts and workforce reductions at the National Institutes of Health. Highlighting the cancellation of over 2,100 research grants and freezes on university funding, the protest underscores concerns over politicization that threatens scientific progress and clinical trials. The declaration warns these measures compromise research quality, efficiency, and global collaborations, calling on NIH leadership for prompt reversal of these policies to safeguard lifesaving research.