The Long Life Family Study (LLFS) secured $80 million in NIH funding to expand a longevity cohort and apply Pacific Biosciences’ Revio HiFi long‑read sequencing to as many as 7,800 participants. The McDonnell Genome Institute at WashU will generate long‑read genomic and epigenomic data to detect structural variants, repeat expansions, indels and methylation signatures linked to resilient aging. Investigators plan integrated analyses combining phenotypes, proteomics, microbiomes and somatic mutation profiling to identify genomic factors tied to healthy longevity and disease resistance. The study will initially sequence ~5,500 samples in Q4 and aims to extend coverage and diversify cohorts, including families of African ancestry, strengthening long‑read datasets for aging research.