Innovative diagnostic approaches employing multi-omics and AI are transforming disease detection and monitoring. Dana-Farber revealed MARLIN, a methylation plus AI-based tool that rapidly subtypes acute leukemia for improved precision oncology. Meanwhile, a new guideline, CHART, standardizes reporting for AI chatbot health advice research, streamlining clinical evaluation of these tools. A lipidomics resource called the Neurolipid Atlas maps brain lipids across cell types and disorders, advancing neurodegenerative disease understanding. These technologies reflect the integration of system biology and computational analytics in diagnostics.