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Terasaki Institute and Caltech win $2.8M CIRM grant — embryo formation research
The Terasaki Institute for Biomedical Innovation and Caltech received a $2.8 million Discovery Stage Research grant from CIRM to advance studies of early human embryo formation. The funded work...
Intranasal nanogel therapeutic vaccine prevents HPV-driven cervical tumors in animals
Chiba University researchers reported preclinical data showing a cationic nanogel–based intranasal vaccine targeting HPV16 E7 antigen elicits local cervicovaginal CD4+ and CD8+ T-cell responses...
Non‑GM immortalization of bovine cells — scalable step for cultivated beef
Researchers at Hebrew University of Jerusalem and Believer Meats described a method to induce stable self-renewal in bovine cells without genetic modification, activating telomerase and PGC1α...
DeepTarget: AI uncovers drug mechanisms — computational route to new cancer targets
Researchers at Sanford Burnham Prebys and collaborators released DeepTarget, a computational platform that predicts anti-cancer mechanisms of small molecules by integrating multi-omic and chemical...
Targeted genetic test improves XDP diagnosis — resolves hidden causes in Filipino patients
Scientists at Brigham and Women’s Hospital and Harvard Medical School developed a targeted genetic assay to better diagnose X‑linked dystonia‑parkinsonism (XDP), a debilitating neurogenetic...
Merck to buy Cidara for $9.2B: bet on long‑acting flu prevention
Merck has agreed to acquire Cidara Therapeutics for roughly $9.2 billion to secure CD388, a long‑acting antiviral designed to prevent seasonal and pandemic influenza. The deal centers on CD388, a...
FDA clamps down on Elevidys: boxed warning and ambulatory restriction
The FDA revised the label for Sarepta’s Duchenne muscular dystrophy gene therapy Elevidys, adding a boxed warning and narrowing use to ambulatory patients while requesting post‑marketing data. The...
Lundbeck ignites Avadel bidding war — Alkermes under pressure
Lundbeck submitted an unsolicited higher bid for Avadel Pharmaceuticals, topping Alkermes’ earlier agreement and triggering a potential bidding contest for the Irish drugmaker’s sleep therapy...
CHMP recommends five products — Telethon‑backed gene therapy surfaces
The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) recommended five new products, including a gene therapy developed by Fondazione Telethon for Wiskott‑Aldrich...
Tumor‑infiltrating lymphocytes: approval momentum and manufacturing gaps
Adoptive cell therapy using tumor‑infiltrating lymphocytes (TILs) has advanced with recent regulatory approvals, but scaling manufacturing, selection, and logistics remain the primary barriers to...
AAV toolbox expands: point‑of‑care antibody screen and vascular‑tropic variants
Researchers unveiled a point‑of‑care test for AAV8 binding antibodies and reported discovery of AAV variants with improved transduction of human vascular endothelial cells, expanding tools to...
NGS automation and standards accelerate clinical genomics workflows
Volta Labs and New England Biolabs struck a partnership to integrate NEBNext library‑prep chemistry with Volta’s Callisto automated platform, while vendors rolled out new NGS and reference...
VGLUT3 gene therapy restores hearing in aged mice
Researchers delivered a VGLUT3 gene therapy to inner hair cells and restored auditory function in aging mice, demonstrating a potential route to treat age‑related hearing loss by repairing...
Scientists immortalize bovine cells without genetic engineering — cultivated beef scale‑up
A team at Hebrew University and Believer Meats reported a non‑genetically modified method to extend bovine cell self‑renewal by activating telomerase and PGC1α, producing stable, self‑renewing cow...
Machine learning predicts DCD donor death — slashes futile liver procurements
Stanford Medicine and Kyoto University researchers developed a machine‑learning model that predicts whether donation‑after‑circulatory‑death (DCD) donors will die within the time window suitable...
Merck stakes $9.2B on long‑acting flu drug — Cidara takeover
Merck announced a $9.2 billion agreement to acquire Cidara Therapeutics to secure CD388, a long‑acting, broadly active influenza prevention candidate now in a Phase III trial. Merck said it will...
FDA tightens Elevidys label: boxed warning, use narrowed
The U.S. Food and Drug Administration revised the label for Sarepta’s Duchenne gene therapy Elevidys, adding a boxed safety warning and restricting use to ambulatory patients. The agency also...
AAV arms race... point‑of‑care antibody test and new capsids emerge
Two developments targeted at adeno‑associated virus (AAV) gene therapy delivery surfaced: a point‑of‑care test for anti‑AAV8 binding antibodies and discovery of AAV variants that markedly improve...
Intranasal nanogel vaccine slows HPV‑driven cervical tumors — preclinical win
Researchers at Chiba University reported a cationic nanogel nasal therapeutic vaccine (cCHP‑E7 + c‑di‑AMP) that induces localized T‑cell responses and limits HPV16 E7‑driven tumor growth in mice...
Prime‑editing inversion method scales chromosomal rearrangements — PIE reported
Scientists published Prime‑Editing‑Based Inversion with Enhanced Performance (PIE), a technique that enables efficient, large‑scale inversion of genomic DNA at chromosomal scale in mammalian...