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LowLoad‑qPCR spots low‑load bacteremia – diagnostic sensitivity improved
Researchers described LowLoad‑qPCR, a refined quantitative PCR protocol that improves detection of low‑load bacteremia—bloodstream infections with low bacterial counts that commonly evade standard...
CDH17+, tight‑junction tumor cells identified as liver‑metastasis instigators
A Nature Communications study identified a discrete subset of tumor cells—tight junction‑high and CDH17‑positive—that act as primary instigators of colorectal cancer liver metastases. The authors...
Ultragenyx, Mereo: setrusumab misses Phase III – expense cuts planned
Ultragenyx and partner Mereo reported that setrusumab failed to meet primary endpoints in two Phase III trials for brittle bone disease (osteogenesis imperfecta), prompting immediate operational...
St. Jude: new method spots off-targets from base editors
St. Jude Children’s Research Hospital published a new method intended to improve detection of small off-target edits generated by base editors, the team said. The approach provides a...
BEAVER trial: binimetinib–encorafenib show responses in non‑V600E BRAF tumors
The Phase II BEAVER trial reported tumor responses to the MEK inhibitor binimetinib combined with the BRAF inhibitor encorafenib in patients with advanced solid tumors harboring non‑V600E BRAF...
Autologous CD133+ cells: early trial suggests repair for Asherman
A Phase 1/2 clinical trial tested autologous CD133+ bone marrow–derived stem cells for Asherman syndrome and reported preliminary signals of endometrial repair, investigators said. The single-arm...
SMLM imaging: extracellular vesicle DNA tracked inside recipient cells
Researchers deployed single-molecule localization microscopy (SMLM) to visualize extracellular vesicle (EV) DNA dynamics inside recipient cells, reporting direct imaging of EV-borne nucleic acids...
Acute exercise reshapes immune cell proteome – Nature Communications study
A new Nature Communications report shows that acute exercise triggers rapid and widespread remodeling of the proteomic architecture in human immune cells, researchers Walzik, Joisten and Metcalfe...
CDH17+ tight-junction cells: new drivers of colorectal liver metastases
A Nature Communications study identified a subpopulation of tight-junction–high, CDH17‑positive colorectal tumor cells as principal drivers of liver metastasis, reporting functional and molecular...
MIS‑C biomarkers... serum panel tracks severity and recovery
A Pediatric Research paper from Wolff and Koutroulis mapped serum immune biomarkers that correlate with disease severity and recovery trajectories in Multisystem Inflammatory Syndrome in Children...
Romosozumab edges PTH analogs in fracture prevention – study
A recent comparative study published in Biol Sex Differ reported that romosozumab outperformed parathyroid hormone (PTH 1–34) analogs in reducing osteoporotic fractures among women, finding...
AI in digital pathology: accuracy gains collide with deployment hurdles
A sector review on AI in digital pathology outlined recent innovations, validation challenges, and integration barriers that laboratories face when deploying machine‑learning tools for...
St. Jude unveils assay: finds off-target edits missed by others
St. Jude Children’s Research Hospital published a new assay that improves detection of small off-target edits produced by base editors. The team released the method to enable researchers and...
BEAVER trial: binimetinib–encorafenib show activity in non‑V600E BRAF tumors
The Phase II BEAVER trial reported clinical activity for the MEK inhibitor binimetinib combined with the BRAF inhibitor encorafenib in advanced solid tumors harboring non‑V600E BRAF alterations....
Insilico surges after Hong Kong listing: finance report
BioCentury’s finance roundup reports a significant market gain for Insilico following its Hong Kong listing. The coverage details the capital infusion and market valuation shifts that followed the...
Harmeier returns to lead Roche venture fund — BioCentury report
BioCentury reports that Harmeier has returned to lead the Roche venture fund, a management move that revises leadership at one of Big Pharma’s principal corporate venture arms. The write‑up lists...
Mapping MASH: liquid biopsy partnership launched
Hepta and collaborators announced a liquid biopsy technology and a landmark partnership to map the biology of metabolic dysfunction‑associated steatohepatitis (MASH). Hamed Amini described a...
Engineered co‑signaling receptors: reduce T‑cell off‑target reactivity
A study led by Cabezas‑Caballero and colleagues reports engineered co‑signaling receptors that improve T cell precision by limiting off‑target activation. The team demonstrated that redesigned...
Phase 1/2: autologous CD133+ stem cells tested for Asherman
Researchers reported a Phase 1/2 trial testing autologous CD133+ bone marrow‑derived stem cells for Asherman syndrome, a fibrotic uterine condition. The trial evaluated feasibility, safety and...
Live tumor‑fragment platform: predicts immunotherapy ex vivo
A team introduced a live tumor‑fragment platform that preserves tumor architecture to assess immunotherapy responses ex vivo. The system allows drug exposure and readout of immune‑mediated tumor...