Get the Daily Brief
Latest Biotech News
61‑day pig kidney study maps immune rejection – a xenotransplantation 'encyclopedia'
Researchers published a multiomics investigation of a pig kidney transplanted into a brain‑dead human subject and monitored for 61 days. The work provides an integrated atlas of physiological and...
Nuvalent’s ALK drug posts responses – FDA talks loom vs Pfizer’s Lorbrena
Nuvalent reported Phase 1/2 data for neladalkib in ALK‑positive lung cancer showing tumor shrinkage in a meaningful subset of heavily pretreated patients and durable responses at 12–18 months in...
Solve raises $120M to advance ADCs – linkers aim to fix historical limits
Solve Therapeutics closed a $120 million financing round to advance two antibody‑drug conjugates and scale its novel linker chemistry. The startup, founded by members of the former VelosBio team...
Sofinnova sews up €650M fund — more capital for early therapeutics
Sofinnova Partners closed Capital XI at €650 million (about US$750 million), exceeding its target to back early‑stage biopharma and medtech companies. The firm said the fund will lengthen its...
Foli‑seq captures host RNA in feces — a new noninvasive gut immune readout
Researchers introduced exfoliome sequencing (Foli‑seq), a method that profiles host mRNA from exfoliated eukaryotic cells in feces to monitor intestinal and immune function. The technique yields...
WHO prequalifies BD Onclarity HPV test – expands screening in low‑resource settings
The World Health Organization granted prequalification to Becton Dickinson’s Onclarity HPV assay for use on BD Cor and BD Viper LT molecular platforms, clearing the test for procurement in low‑...
Korro stock collapses after RNA‑editing miss — restructures to extend runway
Korro Bio’s shares plunged about 81% after Phase I/IIa REWRITE data for KRRO‑110 failed to reach projected alpha‑1 antitrypsin (AAT) thresholds. The company reported insufficient functional M‑AAT...
Merck to buy Cidara for $9.2B — Adds long‑acting influenza antiviral
Merck agreed to acquire Cidara Therapeutics for about $9.2 billion to add CD388, a long‑acting neuraminidase inhibitor–Fc conjugate, to its antiviral portfolio. Cidara’s Phase IIb NAVIGATE results...
Nuvalent posts ALK response rates — Eyes fast FDA filing
Nuvalent reported Phase 1/2 data for neladalkib showing tumor shrinkage in a significant subset of ALK‑positive lung cancer patients whose disease progressed after prior ALK inhibitors. The...
Stem cell transplant restores primate hand function — Major translational step
Researchers published in Nature Biotechnology that transplanting human embryonic stem cell–derived spinal cord neural stem cells (H9‑scNSCs) restored forelimb function in rhesus monkeys with...
CRISPR edit of NRF2: reverses chemotherapy resistance in lung cancer
Scientists at ChristianaCare’s Gene Editing Institute reported a CRISPR‑based approach that targets NRF2 to overcome chemotherapy resistance in lung cancer models. The lead sentence of the study...
Solve pulls $120M — Moves two ADCs toward clinic
Solve Therapeutics raised $120 million to advance two antibody‑drug conjugates (ADCs), and the company said the financing will support ongoing preclinical and early clinical development. Backed by...
Artios pockets $115M — Fuels DNA‑damage repair oncology programs
Artios Pharma closed a $115 million financing to accelerate clinical programs targeting DNA damage response pathways, building on the company’s strategy of exploiting tumor DNA‑repair dependencies...
Lilly taps ABL Bio: $40M upfront, $2.6B total
Eli Lilly signed a deal with Seoul‑based ABL Bio that includes $40 million upfront and up to $2.56 billion in milestone payments to access South Korean assets and platforms. The agreement grants...
LexicMap: Searches world’s microbial genomes in minutes
Nature Biotechnology published LexicMap, an algorithm that can search millions of bacterial and archaeal genomes for genes and mutations in minutes—addressing the scaling problem as genomic...
Foli‑seq captures the fecal exfoliome — Noninvasive gut immune monitoring
Researchers introduced exfoliome sequencing (Foli‑seq), a method to profile host mRNAs from shed intestinal cells in feces to track gut epithelial and immune dynamics noninvasively. Published in...
Rapid AAV8 antibody test — New AAV variants expand vascular targeting
Two gene‑therapy enabling advances appeared: a point‑of‑care test for AAV8‑binding antibodies built on Chembio’s Dual Path Platform, and discovery of AAV variants that markedly improve...
Merck to acquire Cidara for $9.2B — Adds Phase III influenza candidate
Merck agreed to buy Cidara Therapeutics for roughly $9.2 billion to add CD388, Cidara’s long‑acting neuraminidase inhibitor–Fc conjugate, to its antiviral portfolio. The drug is in a Phase III...
Sofinnova closes €650M fund — Pumps capital into clinic‑ready drugmakers
Sofinnova Partners closed a €650 million flagship fund (Capital XI) to back early‑stage biotech and medtech companies, with about 20%–30% earmarked for devices. The firm said it has already...
Korro stock craters 81% — Data miss forces layoffs and R&D pivot
Korro Bio’s shares plunged 81% after Phase I/IIa REWRITE data missed projections for its RNA editing oligonucleotide KRRO‑110 in alpha‑1 antitrypsin deficiency (AATD). The trial showed functional...