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Roche–Zealand peptide meets endpoints — obesity readout shows tolerability, modest weight loss
Zealand Pharma and Roche reported Phase 2 results for petrelintide, an amylin-receptor–targeting peptide, showing tolerability comparable to placebo but average weight loss below some analyst...
New high-throughput DnD assay finds hidden antibiotic resistances — diagnostic advance
Researchers Ma and Kim published a dilution‑and‑delay (DnD) susceptibility assay in Nature Communications that detects previously hidden antibiotic resistance phenotypes at high resolution and...
Study maps new HIV‑1 lenacapavir resistance paths — implications for long‑acting therapy
A Nature Communications study by Orris, Siddiqui, Tang and colleagues delineated recurrent and novel evolutionary routes HIV‑1 takes to escape lenacapavir, a long‑acting capsid inhibitor used in...
Targeting ITK enhances anti‑CD19 CAR‑T potency — preclinical route to better cell therapies
Researchers reported that inhibiting ITK (interleukin‑2‑inducible T‑cell kinase) can remodel CAR‑T cells to improve anti‑CD19 therapeutic activity in preclinical models. The strategy altered...
Low‑cost sample hashing scales single‑cell multiomics — clinical sample workflows advance
A new workflow built around Seq‑Well enables scalable, low‑cost sample hashing for single‑cell multiomics, improving throughput for precious clinical samples. The method streamlines barcoding and...
Penn unveils sub‑millimeter robots with sensors and onboard compute — medical microrobotics step
Researchers at the University of Pennsylvania led by Marc Miskin introduced sub‑millimeter robots equipped with sensors, a motor, onboard computation and tiny solar cells to power movement and...
Phase III ACWY‑TT vaccine shows safety and efficacy in toddlers — pediatric meningococcal option advances
A Phase III trial of a quadrivalent meningococcal ACWY‑TT conjugate vaccine in infants aged 6 to 23 months conducted in the U.S. and Puerto Rico demonstrated favorable immunogenicity and safety,...
ESC issues patient‑facing pregnancy CVD guidance — shared decision tools released
The European Society of Cardiology published a patient‑focused version of its guidelines addressing cardiovascular disease management during pregnancy, released on International Women’s Day. The...
Servier boosts rare-cancer push: $2.5B Day One buyout
Servier agreed to acquire Day One Biopharmaceuticals for about $2.5 billion, adding the FDA‑approved pediatric glioma drug Ojemda and an early-to-late stage oncology pipeline to its portfolio. The...
Vinay Prasad to depart FDA again — exit set for end of April
Vinay Prasad, director of the FDA’s Center for Biologics Evaluation and Research, will leave the agency at the end of April after a turbulent tenure marked by high‑profile rejections and reversals...
FDA doubles down: uniQure must run sham‑controlled Huntington’s trial
The FDA reaffirmed its requirement that uniQure perform a sham‑controlled randomized trial before accepting a Biologics License Application for AMT‑130, the company’s gene therapy for Huntington’s...
Petrelintide misses lofty bar—Roche/Zealand readout disappoints investors
Roche and Zealand Pharma reported Phase 2 data for petrelintide showing roughly 10.7% mean placebo‑controlled weight loss at 42 weeks, falling short of investor expectations and triggering a sharp...
High‑throughput DnD assay: new tool to unmask hidden antibiotic resistance
Researchers published a scalable dilution‑and‑delay (DnD) susceptibility assay that resolves low‑frequency and inducible antibiotic resistance phenotypes missed by standard tests. The Nature...
New study maps lenacapavir resistance — HIV finds recurrent and unique escape routes
A Nature Communications paper by Orris, Siddiqui, Tang and colleagues delineates evolutionary pathways HIV‑1 uses to escape lenacapavir, an extended‑release capsid inhibitor. The team identified...
CAR‑astrocytes prevent and reduce amyloid plaques in mice — single injection effect
A team at Washington University engineered astrocytes expressing chimeric antigen receptors (CAR‑As) that target amyloid‑β and demonstrated prevention and partial reversal of plaque pathology in...
FDA clears Claire: Perimeter wins approval for intraoperative AI margin imaging
Perimeter Medical Imaging AI received FDA premarket approval for Claire, an AI‑driven wide‑field optical coherence tomography system designed to image excised breast tissue margins during surgery....
Japan approves first iPSC‑derived therapy for Parkinson’s — regulatory milestone
Japanese regulators approved the first therapy derived from induced pluripotent stem cells (iPSCs) to treat Parkinson’s disease, marking a world first for iPSC‑based regenerative medicine. The...
Penn unveils microscopic robot — sub‑millimeter machines pack sensors and solar power
Researchers at the University of Pennsylvania described a microscopic robot under one millimeter long that integrates sensors, an onboard computer, a motor and tiny solar cells to convert light...
Prasad to leave FDA: departure caps tumultuous term
Vinay Prasad will depart the Food and Drug Administration at the end of April, concluding a turbulent tenure that saw heightened scrutiny of vaccine and rare-disease reviews. Reports from AP and...
FDA stands by sham-control demand: uniQure fight intensifies
The FDA defended its decision to require a sham-controlled trial for uniQure’s AMT-130 gene therapy for Huntington’s disease, telling reporters that the agency asked the company to randomize...