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Corporate and industry leadership, acquisitions, and strategic deals
Key corporate developments and strategic deals marked the biotech and pharma landscape. Bayer extended CEO Bill Anderson's contract through March 2029 to continue transformation efforts. Sino...
Sarepta Therapeutics Restructures Amid DMD Therapy Safety Concerns
Sarepta Therapeutics announced a major restructuring, cutting approximately 36% of its workforce—about 500 jobs—following the deaths of two Duchenne muscular dystrophy (DMD) patients treated with...
Mitochondrial Donation Yields Healthy Babies with Three-Person DNA Technique
Researchers in the UK have reported the birth of eight healthy babies born using mitochondrial donation, an IVF technique involving DNA from three individuals—two parents and a mitochondrial...
GLP-1/GIP Dual Agonist Shows Promising Weight Loss in China Phase III Trial
A joint development by Jiangsu Hengrui Pharmaceuticals and Kailera Therapeutics of a once-weekly injectable dual GLP-1/GIP receptor agonist demonstrated significant weight loss of approximately...
FDA Reviews Safety and Efficacy Concerns for GSK’s Blenrep in Multiple Myeloma
Ahead of the July 17 advisory committee meeting, the FDA raised concerns about the ocular toxicity profile and dose optimization of GSK's antibody-drug conjugate Blenrep for relapsed or refractory...
Advanced Mapping Reveals Brain Blood-Flow Regulation via Endothelial Connexins
New research from Harvard Medical School and collaborators uncovered that specific endothelial gap junction proteins, connexins Cx37 and Cx40, enable rapid communication along brain blood vessels,...
Innovative Molecular and AI Platforms Accelerate Drug Discovery and Biomanufacturing
Dalriada announced a strategic collaboration with a public computational company to apply its iCLASS proteomics platform combined with computational technologies for novel drug discovery....
Biopharma Dealmaking Remains Strong with Multiple High-Value Transactions
Biopharma deal value surged past $138 billion in the first half of 2025, fueled by large transactions including Sino Biopharmaceutical’s acquisition of LaNova Medicines for up to $951 million and...
Protein and Proteomics Research Illuminate Neurodegenerative Disease Mechanisms
The Global Neurodegeneration Proteomics Consortium released one of the world’s largest dementia-related protein datasets containing about 250 million protein measurements from over 35,000 samples...
Novel Microbiome Metabolite Identified as Driver and Therapeutic Target in Atherosclerosis
New research from the Centro Nacional de Investigaciones Cardiovasculares (CNIC) identifies imidazole propionate (ImP), a gut microbiota-derived metabolite, as associated with early active...
Brain Blood Flow Mechanism Decoded in Mice: Connexin Proteins Key
Scientists from Harvard Medical School, the Broad Institute, and Weill Cornell Medicine have elucidated how the brain rapidly redirects blood flow to active regions. Utilizing optogenetics and...
Sarepta Therapeutics Restructures After DMD Therapy Safety Setbacks
Sarepta Therapeutics is cutting approximately 36% of its workforce—about 500 jobs—following the deaths of two Duchenne muscular dystrophy patients treated with its gene therapy Elevidys. The...
Eight Healthy Babies Born via Mitochondrial Donation Trial in UK
UK researchers announced the birth of eight infants conceived through mitochondrial donation using pronuclear transfer, preventing transmission of mitochondrial DNA disease. This technique...
Non-Antibiotic Drugs Disrupt Gut Microbiome’s Pathogen Defense
Recent studies reveal that common non-antibiotic medications can impair the gut microbiome's ability to resist colonization by harmful pathogens. This disruption may arise through alterations in...
GLP-1/GIP Dual Agonist Shows Significant Weight Loss in China Phase III Trial
Jiangsu Hengrui Pharmaceuticals and Kailera Therapeutics reported that their dual-acting GLP-1/GIP receptor agonist induced nearly 18% mean weight loss at 48 weeks in obese patients during a Phase...
FDA Scrutiny of GSK’s Blenrep Questions Safety and Efficacy Ahead of Advisory Panel
Ahead of the July 17 advisory committee meeting, FDA reviewers expressed concerns over GSK's antibody-drug conjugate Blenrep’s ocular toxicity, high rates of dose modifications, and unclear...
Nuclidium Raises $98M Series B to Advance Copper-Based Radiotheranostics
Swiss-German radiopharmaceutical company Nuclidium closed a $98 million Series B financing to accelerate development and production of its copper-61 and copper-67 radiotheranostic agents for...
Biotx AI Uses GWAS Data for Drug Target Discovery and Repurposing
German startup Biotx AI leverages a vast curated genome-wide association study (GWAS) dataset with phenotypic and drug molecule data to predict disease causality and identify optimal drug targets....
Large-Scale Neurodegeneration Proteomics Consortium Identifies Biomarkers and Mechanisms
The Global Neurodegeneration Proteomics Consortium (GNPC) released one of the largest proteomic datasets comprising approximately 250 million protein measurements from over 35,000 biosamples....
CalPERS Switches Pharmacy Benefit Manager to CVS Caremark for 587,000 Members
California Public Employees’ Retirement System (CalPERS) has signed a five-year contract with CVS Caremark to provide outpatient prescription drug benefits for approximately 587,000 members...