Scientists are making significant strides in mapping brain activity and cellular behaviors. Harvard and Broad Institute teams identified endothelial connexin clusters critical for propagating vasodilation linked to neural activity, with implications for CNS diseases. Studies also spotlight neutrophils and extracellular traps as drivers of vascular blockage and metastasis in tumors, revealing new cancer progression pathways. These insights are likely to open avenues for innovative therapies targeting neurovascular and cancer biology.