A team led by Tulane University and Shenzhen Third People's Hospital developed an improved one-pot CRISPR assay for tuberculosis utilizing recombinase polymerase amplification alongside CRISPR-Cas12a. The test detects TB from non-sputum samples like cheek swabs or stool in under an hour at room temperature, addressing diagnostic gaps in low-resource settings. High sensitivity and cost-effectiveness promise to enhance community-based TB screening and reduce undiagnosed cases, especially where sputum collection is difficult.