Research led at Max Delbrück Center reveals PIEZO2 ion channels govern coronary vessel development in embryos, extending their known function beyond mechanosensation. Mouse models show both loss and hyperactivity of PIEZO2 disrupt vessel maturation, causing cardiac abnormalities. Findings, published in Nature Cardiovascular Research, link PIEZO2 dysfunction to congenital heart defects and human syndromes, opening pathways for targeted therapies.