Researchers revealed structural and mechanistic details of bacterial regulation of ribonucleotide reductase (RNR) expression via the NrdR regulator, illuminating a control node unique to prokaryotes and a potential selective antimicrobial target. The work describes how NrdR senses nucleotide pools and modulates RNR transcription, offering routes to inhibit bacterial DNA synthesis without affecting eukaryotic counterparts. The study, reported in structural biology briefings and research releases, highlights a pathogen‑selective vulnerability that could seed next‑generation antibiotics.