A meta-analysis of sixteen randomized controlled trials found nurse-led interventions significantly reduced alcohol screening scores, consumption, and binge drinking in adults, while also noting limited certainty in the evidence. The pooled analysis emphasizes the role of nurses in behavioral intervention delivery—where clinical workflow and counseling execution can be decisive. The findings align with ongoing efforts to scale pragmatic screening-and-brief-intervention models in primary and specialty settings rather than relying only on pharmacotherapy. However, the analysis also highlights uncertainty, suggesting that effect estimates may vary by study design, intervention intensity, and measurement approaches. For trialists and payers, the data support nurse-led strategies as a viable nonpharmacologic lever for alcohol-related risk reduction, but they underscore the need for higher-quality trials that tighten certainty.