Researchers at Northwestern unveiled HYDRACs, heterobifunctional proteomimetic polymers that recruit cellular degradation machinery to eliminate traditionally undruggable oncogenic drivers MYC and KRAS. In cell lines the polymers selectively degraded targets and triggered cancer cell death; in mice, tumor accumulation and growth inhibition were reported. The work appears in Nature Communications and was led by Nathan Gianneschi. HYDRACs display multiple peptide‑based target recognition elements alongside degron motifs to bring targets to the proteostasis system without requiring classic small‑molecule binding pockets. The approach widens the degradable proteome and suggests a one‑step polymer chemistry route to targeted protein elimination, with implications for cancers driven by intrinsically disordered or pocketless proteins.