Researchers at Northwestern reported a new class of protein‑like polymers—HYDRACs—that recruit cellular degradation machinery to selectively eliminate intrinsically disordered, 'undruggable' oncogenes such as MYC and KRAS. In cell culture HYDRACs triggered target degradation and cancer cell death; in mouse models the polymers accumulated in tumors and slowed growth. The approach uses multivalent polymer displays of binding peptides and degrons to physically link targets to the proteolytic machinery, offering an alternative to small‑molecule ligand discovery when no well‑defined binding pocket exists. The work, published in Nature Communications, presents a potential new modality for tackling high‑value oncology targets.