Recent research offers novel insights into cancer biology and immunotherapy resistance. Notable findings include identification of the GATOR1 complex as a tumor suppressor in Myc-driven lymphoma using CRISPR screens, discovery of the STN1 protein driving pancreatic cancer metastasis, and adipocyte-mediated crosstalk promoting triple-negative breast cancer progression. Additionally, mechanisms behind immunotherapy resistance linked to nerve injury and insights into ferroptosis regulation by ERBB3 in gastric cancer reveal new therapeutic avenues.